THE PD-(D/E)XK SUPERFAMILY REVISITED: IDENTIFICATION OF NEW MEMBERS AMONG PROTEINS INVOLVED IN DNA METABOLISM AND FUNCTIONAL PREDICTIONS FOR DOMAINS OF (HITHERTO) UNKNOWN FUNCTION

Abstract Background The PD-(D/E)XK nuclease superfamily, initially identified in type II restriction endonucleases and later in many enzymes involved in DNA recombination and repair, is one of the most challenging targets for protein sequence analysis and structure prediction.Typically, the sequence similarity between these proteins is so low, that

Introduction.Oligodontia is a dental abnormality in which the patient is missing teeth.It is a hereditary disorder characterized by agenesis of more than six primary or permanent teeth, excluding the wisdom teeth.Oligodontia Bakeware is often related with an abnormal size of teeth, conical shape, taurodontism, frequent enamel abnormalities, and del

RNA interference (RNAi) is an antiviral pathway common to many eukaryotes that detects and cleaves foreign nucleic acids.In mammals, mitochondrially localized proteins such as mitochondrial antiviral signaling (MAVS), retinoic acid-inducible gene I (RIG-I), and melanoma differentiation-associated protein 5 (MDA5) mediate antiviral responses.Here, w

Introduction Literature showed that patients suffering from disorders belonging to the schizophrenic (SZ) and bipolar (DB) spectrum have a qualitatively similar but SUPER MULTI-WITH IRON quantitatively different neurocognitive impairment that correlates with the outcomes.However, the majority of former studies are conducted on patients in remission